Hajoale, ho na le mefuta e ka bang 81 ea litlhare tse thibelang hlahala tse sebelisoang haholo ho tsa bongaka.1. Lithethefatsi tse khahlanong le hlahala li arotsoe ho ea ka mohloli oa tsona le mokhoa oa ho sebetsa.Ka kakaretso arotsoe ka alkylating lithethefatsi, antimetabolites, lithibela-mafu, limela, lihomone le lithethefatsi tse ling.Lithethefatsi tse ling li kenyelletsa platinum, asparaginase, lithethefatsi tse lebisitsoeng ho phekola, joalo-joalo, ntle le li-reagents tsa likokoana-hloko le phekolo ea lefutso.Sehlopha sena se ke ke sa akaretsa tsoelo-pele ea hona joale ea lithethefatsi tse khahlanong le hlahala.Ea bobeli, lihlopha tse ling li itšetlehile ka lipakane tsa limolek'hule tsa lithethefatsi, tse arotsoeng ka lihlopha tse ngata.Sehlopha sa pele ke lithethefatsi tse sebetsang ka sebopeho sa lik'hemik'hale tsa DNA, tse kang alkylating kapa platinum compounds.Sehlopha sa bobeli ke lithethefatsi tse amang nucleic acid synthesis, tse kang antimetabolites.Sehlopha sa boraro ke sethethefatsi se sebetsang ho template ea DNA, se amang ho ngoloa le ho thibela DNA, le ho thibela motsoako oa RNA ka ho itšetleha ka RNA polymerase.Sehlopha sa bone ke lithethefatsi tse amang protheine synthesis, tse kang paclitaxel, vinblastine joalo-joalo.Sehlopha sa ho qetela ke mefuta e meng ea lithethefatsi, joalo ka lihormone, asiti ea aspartic, lithethefatsi tse lebisitsoeng ho kalafo, joalo-joalo, empa lithethefatsi tsa morao-rao tse thibelang hlahala li ntse li tsoela pele ka potlako, 'me lihlopha tse kaholimo ha li khone ho akaretsa lithethefatsi tse seng li ntse li le teng. ho kena tleliniking..“

Hona joale, ho na le lithethefatsi tse ngata tse khahlanong le hlahala mesebetsing ea bongaka.Ka mohlala,oxaliplatin, fluorouracil, le irinotecan e ka sebelisoa bakeng sa lihlahala tsa ka mpeng.Bakuli ba nang le mofetše oa mala ba ka phekoloa ka lithethefatsi tse kangcisplatinlepaclitaxel.Ka kakaretso, mefuta e fapaneng ea mofetše e khetha meriana e fapaneng.Ntle le moo, bakuli ba mofets'e ba ka phekoloa ka lithethefatsi tse lebisitsoeng ho molek'hule, joalo ka erlotinib, osimertinib, cetuximab le lithethefatsi tse ling.

Lithethefatsi tse tloaelehileng tsa anti-tumor tse bakang CIPN li kenyelletsaPaclitaxelPlatinum, Vinblastine,MethotrexateFluorouracil, Ifosfamide,CytarabineFludarabine, Thalidomide,Bortimiazolejoalo joalo.

Paclitaxel e sebelisa ntlha ea kholo ea methapo ho fokotsa kapa ho khutlisa neurotoxicity;cisplatin e sebelisa glutathione e fokotsehileng le amifostine ho thibela lefu la methapo le bakoang ke eona;Oxaliplatin ha e kopane le ts'usumetso e batang nakong ea ts'ebeliso ho thibela ho tsosoa ha serame ho ama methapo ea kutlo Ho susumetsa, ts'ebeliso ea motsoako oa calcium-magnesium e ka fokotsa sekhahla le matla a matšoao a hlobaetsang a neurotoxicity, le ho liehisa ho hlaha ha neuropathy;ifosfamide e ka khetha methylene blue ho thibela neurotoxicity;sebelisa thiamine bakeng sa fluorouracil ka thibela methapo Phello e chefo.